庄诗美
1987年毕业于上海医科大（现复旦大学上海医学院），临床医学专业；
1992年于上海医科大学获儿科学医学博士学位，后被该校医学神经生物学国家重点实验室聘为讲师；
1993-1994年作为访问学者在荷兰Leiden大学从事细胞信号传导的研究工作；
1995-2002年于瑞典Linkoping大学从事化学物致癌机理研究，其间于1999年获细胞生物学博士学位，于2000年被聘为助理教授；
2002年受聘教育部“长江学者”特聘教授，回国任教于中山大学；
2009年获国家杰出青年科学基金资助；
2010年获国务院政府特殊津贴；
2013年入选国家“百千万人才工程”有突出贡献中青年专家；
2014年入选“广东特支计划”百千万领军人才。
长期以来从事癌变分子机制和细胞信号传导领域的研究工作。课题组结合细胞和动物模型以及临床标本，系统研究了肝癌发生发展的分子机制，尤其是miRNA与长非编码RNA的功能网络及其在肝癌发病中的作用。对miRNA的研究主要针对一批在肝癌中显著下调的miRNAs（miR-101、miR-122、miR-125b、miR-195、miR-26和miR-29）的功能和调控机制，已有的研究成果不仅从新的角度揭示了肝癌的发病机制，为肝癌防治提供了新的靶点，而且对细胞信号调控网络做了重要补充。
近年来，作为通讯作者在Hepatology、Cancer Research、Oncogene等国际知名刊物发表多篇高水平研究论文，作为第一发明人获授权国家发明专利6项，同时作为主持人承担了科技部“973”、“863”课题，国家自然科学基金面上、重点和杰青项目，以及多个省部级课题。
近期代表性论文（通讯作者*）：
[1] Na Zhao, Si-wen Li, Rui-zhi Wang, Man-huan Xiao, Yu Meng, Chun-xian Zeng, Jian-Hong Fang, Jin-e Yang, Shi-Mei Zhuang*.Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells.Biochim Biophys Acta - Gene Regulatory Mechanisms 2016 Jul;1859(7):933-42.
[2] Zhang C, Wu M, Zhang L, Shang LR, Fang JH, Zhuang SM. Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling. Oncotarget 2016, 7 (29): 45702-45714
[3] Xue-Jia Lin, Yutian Chong, Zhi-Wei Guo, Chen Xie, Xiao-Jing Yang, Qi Zhang, Sheng-Ping Li, Yujuan Xiong, Yunfei Yuan, Jun Min, Wei-Hua Jia, Yusheng Jie, Min-Shan Chen, Mei-Xian Chen, Jian-Hong Fang, Chunxian Zeng, Yaojun Zhang, Rong-Ping Guo, Yuankai Wu, Guoli Lin, Limin Zheng, Shi-Mei Zhuang*. A serum-microRNA classifier for the early detection of hepatocellular carcinoma: a multicenter and retrospective longitudinal repository study. The Lancet Oncology 2015, 16(7):804-15.
[4] Jian-Hong Fang, Hui-Chao Zhou, Chong Zhang, Li-Ru Shang, Lei Zhang, Jing Xu, Limin Zheng, Yunfei Yuan, Rong-Ping Guo, Wei-Hua Jia, Jing-Ping Yun, Min-Shan Chen, Yaojun Zhang, Shi-Mei Zhuang*. A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an EMT-independent manner. Hepatology 2015, 62(2):452-65.
[5] Chunxian Zeng, Yun-Long Wang, Chen Xie, Ye Sang, Tuan-Jie Li, Min Zhang, Ruizhi Wang, Qi Zhang, Limin Zheng, Shi-Mei Zhuang*. Identification of a novel TGF-b-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis. Oncotarget 2015, 6(14):12224-33.
[6] Hui-Chao Zhou, Jian-Hong Fang, Xu Luo, Lei Zhang, Jine Yang, Chong Zhang, Shi-Mei Zhuang*. Downregulation of MicroRNA-100 Enhances the ICMT-Rac1 Signaling and Promotes Metastasis of Hepatocellular Carcinoma Cells. Oncotarget 2014, 5(23):12177-88.
[7] Jing-Jing Liu, Xue-Jia Lin, XiaoJing Yang, Liangji Zhou, Shuai He, Shi-Mei Zhuang*, Jine Yang*. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res 2014, 42(19):12041-51.
[8] Yi-Yuan Ge, Qing Shi, Zhi-Yuan Zheng, Jiao Gong, Chunxian Zeng, Jine Yang and Shi-Mei Zhuang*. MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R.Oncotarget 2014, 5(15):6218-28.
[9] Na Zhao, Ruizhi Wang, Liangji Zhou, Ying Zhu, Jiao Gong, Shi-Mei Zhuang*. MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Molecular Cancer 2014, 13(1):35.
[10] Jing-Ping Zhang, Chunxian Zeng, Li Xu , Jiao Gong , Jian-Hong Fang, Shi-Mei Zhuang*. MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling. Oncogene 2014, 33(31):4069-76.
