性别:男
职称: 副教授
学历: 博士
电子邮件: dongchfu@mail.sysu.edu.cn
导师类型: 博士生导师
学科方向:071004-水生生物学
0860-生物与医药

 

研究方向

 水生经济动物病毒性病害之病原生物学、疫苗学与免疫生物学   

学术成就

   早期主要从事水生经济动物细菌性病害的研究，包括大宗淡水鱼常见细菌病和海水养殖鱼类弧菌病，在国内首先分离、鉴定并保种极高毒力鳗鲡创伤弧菌（生物Ⅰ型），发表中文核心期刊文章18篇

  2005年至今主要从事水生经济动物病毒性病害的病原生物、免疫和疫苗方面的研究工作。主持国家重点研发、广东省重点研发、国家自然科学基金青年、面上，973子课题、博士后基金面上（一等）、博士后特别基金、教育部中央高校基金、中山大学应用性成果转化基金等。

1.在国内率先建立了对淡、海水鱼类ISKNV型和RSIV型肿大细胞病毒长期持续高敏感MFF-1传代细胞系(Dong et al., Virus Res, 2008; 2010)，系统解决了ISKNV型和RSIV型肿大细胞虹彩病毒的规模化细胞培养、结构蛋白解析、细胞疫苗研制及免疫学诊断（单抗）等学科领域内关键科学问题；

作为技术核心研制的《鳜传染性脾肾坏死病灭活疫苗（NH0618株）》获国家一类新兽药证书【（中华人民共和国农业农村部公告第253号，（2019）新兽药证字75号）】，当前在全国范围大面积批签发应用。

2.建立锦鲤疱疹病毒/鲤疱疹病毒3型（KHV/CyHV-3）和鲫鱼/金鱼2型疱疹病毒（CyHV-2/GFHNV）的培养体系和完善研究平台。在国内率先分离、培养并纯化到锦鲤疱疹病毒（CyHV3/KHV）本土分离株（含一株在国际上十分罕见的欧--亚过渡性欧洲基因型毒株CyHV-3/KHV-GZ11），建立了完善研究平台；在鲫鱼/金鱼CyHV-2/GFHNV致病机制和疫苗领域取得重大进展。

3.在国内外首先分离、鉴定、培养出黄鳍鲷腹水病源脱磷病病毒(SDDV)，并作系统研究，创制出尖吻鲈/黄鳍鲷/鳜鱼的ISKNV-SDDV高效二联灭活疫苗。

以第一作者或通讯作者在JVI，Virology，Virus Res，Vet Microbiol，Fish & shellfish Immunol, Aquaculture及J Fis Diseases等病毒学/兽医科学/水产学等领域的国际专业期刊发表研究论文40余篇; 发表中文核心期刊论文10余篇。

 

主要学术成果

（一）、研究论文

Peer-reviewed Published Articles(* or**, corresponding author)：

49. Chen, J., Mi, Z., Zhang, W., Luo, P., Weng, S., He, J., & Dong, C*. (2025). Spontaneous development and characterization of an endothelial-like cell line from mandarin fish Siniperca chuatsi. Fish & Shellfish Immunology, 110647.

48. Chen, J., Fu, Y., Li Y., Weng, S., Wang, H., He, J. and Dong, C*., (2025). Transferrin receptor 1 (TfR1) functions as an entry receptor for scale drop disease virus to invade the host cell via clathrin-mediated endocytosis. Journal of Virology, 99(8): e00671-25. 

47. Fu Y.,Mao C., Wan J., Yu F., Sun, J., Wu J., Li, Y. and Dong, C*.,(2025). Detection and Genomic Characterisation of Scale Drop Disease Virus (SDDV) in Farmed Yellowfin Seabream (Acanthopagrus latus) in Southern China. J Fish Dis52, e14161.

46. Zhang, W., Li, Y., Wu, X., Sun, Q., Fu, Y., Weng, S., He, J. and Dong, C*., (2025). Dissection of the global responses of mandarin fish pyloric cecum to an acute ranavirus (MRV) infection reveals the formation of serositis and then ascites. Journal of Virology, 99(6): e02308-24.

45. Chen, J., Fu, Y., Weng, S., He, J. and Dong, C*. (2025). Vitamin C Inhibits Scale Drop Disease Virus Infectivity by Targeting Nrf2 to Reduce Ferroptosis. Antioxidants, 14(5), p.576.

44. Chen, J., Fu, Y., Chen, S., Weng, S., He, J. and Dong, C*., (2025). Scale drop disease virus (SDDV) triggers ferroptosis both in mandarin fish (Siniperca chuatsi) and MFF-1 cells to facilitate virus infection via linking to transferrin receptor 1 (Tfr1). Fish & Shellfish Immunology, p.110416.

43. Li, Z.C., Zhuang, J.Y., Wang, H.B., Cao, J.Z., Wang, B.T., Han, Q., Luo, Z., Dong, C*., Li, A.X*., (2025). Oxidative stress, inflammation, and apoptosis contribute to the pathogenesis of Amyloodinium ocellatum infection in yellowfin seabream (Acanthopagrus latus). Fish & Shellfish Immunology162.

42. Zhuang, J.Y., Li, Z.C., Cao, J.Z., Luo, Z., Wang, B.T., Han, Q., Wang, H.B., Li, H., Wang, C.X., Dong, C*., Li, A.X. *, (2025). A quantitative real-time PCR assay for rapid detection and quantification Amyloodinium ocellatum parasites in seawater samples. Aquaculture595.

41. Ding, S., Li, Y., Sun, Q.Q., Zhu, Z.M., Yu, F.Z., Weng, S.P., He, J.G., Dong, C *., (2025). Dual protection against grouper Rana-Iridovirus (GIV-R) and nervous necrosis virus (NNV) by novel GIV-R-Δ51-NNV-CP chimeric vaccine candidates. Fish & Shellfish Immunology162.

40. Sun, Q.; Ding, S.; Liu, X.; Zhang, W.; Yu, F.; Fu, Y.; Li, Y.; Dong, C*.,(2025). The Co-Infection of ISKNV-II and RGNNV Resulting in Mass Mortality of Juvenile Asian Seabass (Lates calcarifer), Zhuhai, Southern China. J Fish Dis48, e14052. 

39. Zhang, W., Gong, H., Sun, Q., Fu, Y., Wu, X., Deng, H., Weng, S., He, J. and Dong, C*.,(2024). Peripheral B Lymphocyte Serves as a Reservoir for the Persistently Covert Infection of Mandarin Fish Siniperca chuatsi Ranavirus. Viruses, 16(12), 1895. https://doi.org/10.3390/v16121895.

38. Feng Z, Cheng W, Ma M, Yu C, Zhang Y, Lu L, Wang H, Gui L, Xu D*, Dong, C*(2024). Generation and Characterization of ORF55/ORF57-Deleted Recombinant Cyprinid herpesvirus 2 Mutants with Chimeric Capsid Protein Gene of Grouper Nervous Necrosis Virus. Vaccines. 2024; 12(1):43. https://doi.org/10.3390/vaccines12010043

37. Fu, W., Li, Y., Fu, Y., Zhang, W., Luo, P., Sun, Q., Yu Fangzhao, Weng Shaoping, Li Wangdong, He Jianguo and Dong, C*. (2023). The Inactivated ISKNV-I Vaccine Confers Highly Effective Cross-Protection against Epidemic RSIV-I and RSIV-II from Cultured Spotted Sea Bass Lateolabrax maculatus. Microbiology Spectrum, 11(3), e04495-22. 

36. Fu, Y., Li, Y., Chen, J., Yu, F., Liu, X., Fu, W., Pan, H., Li, W., Weng S., He, J., Dong, C*, (2023). A mandarinfish Siniperca chuatsi infection and vaccination model for SDDV and efficacy evaluation of the formalin-killed cell vaccine in yellowfin seabream Acanthopagrus latus Aquaculture 570.

35. Zhang, W., Deng, H., Fu, Y., Fu, W., Weng, S., He, J., & Dong, C*(2023). Production and characterization of monoclonal antibodies against mandarinfish ranavirus and first identification of pyloric caecum as the major target tissue. J Fish Dis, 46(3), 189-199. doi:10.1111/jfd.13733.

34. Fu, Y., Li, Y., Zhang W, Fu, W., Li W, Zhu Z, Weng, S., He, J., Dong, C*, (2023). Effectively protecting Asian seabass Lates calcarifer from ISKNV-I, ISKNV-II, RSIV-II and SDDV by an inactivated ISKNV-I and SDDV bivalent vaccine. Aquaculture 566, 739218.

33. Sun Y, Weng S, Xu B, Dong C*., He J*. (2023). Iron loss and hypoxia are involved in lethal Pseudomonas plecoglossicida infections in the orange-spotted grouper Epinephelus coioides. Aquaculture 563, 739015

32. Fu, Y., Li, Y., Liu, X., Fu, W., Weng, S., Yu, F., He, J., Dong, C*, (2022). Development of two cell lines from yellowfin sea bream (Acanthopagrus latus) fin and brain suitable for propagating SDDV but not for ISKNV, MRV and GIV-R. Aquaculture, 560, 738478

31. Zhang, H., Qi, H., Weng, S., He, J*., & Dong, C*. (2022). Deleting ORF71L of infectious spleen and kidney necrosis virus (ISKNV) resulted in virulence attenuation in Mandarin fish. Fish & Shellfish Immunology.Volume 123, April 2022, Pages 335-347

30. Liu, F., Weng, S., He, J., Dong, C*, (2022). Cyclophilin A is incorporated into cyprinid herpesvirus 3 (CyHV-3) virion via interaction with envelope VP32 and facilitates CyHV-3 replication in in vitro. Aquaculture, 737943.

29. Fu Y, Li Y, Fu W, Su H, Zhang L, Huang C, Weng S, Yu F, He J*, Dong, C*. (2021). Scale Drop Disease Virus Associated Yellowfin Seabream (Acanthopagrus latus) Ascites Diseases, Zhuhai, Guangdong, Southern China: The First Description. Viruses, 13(8):1617. doi: 10.3390/v13081617

28. Zhu Z, Duan C, Li Y, Huang C, Weng S, He J and Dong, C*. (2021).Pathogenicity and histopathology of infectious spleen and kidney necrosis virus genotype II (ISKNV-II) recovering from mass mortality of farmed Asian seabass, Lates calcarifer, in Southern China. Aquaculture, 534 (2021) 736326.

27. Sun Y, Zhu Z, Weng S, He J andDong, C*. (2020). Characterization of a highly lethal barramundi (Lates calcarifer) model of Pseudomonas plecoglossicida infection. Microbial Pathogenesis, 149 (2020), 104516.

26 Zhu Zhiming, Duan Chao, Dong, C*, Weng Shaoping and He Jianguo*. (2020). Epidemiological situation and phylogenetic relationship of Vibrio harveyi in marine-cultured fishes in China and Southeast Asia. Aquaculture, 529 (2020) 735652.

25. Zhang W, Duan C, Weng S, He J and Dong, C*. (2020). Widespread outbreaks of the emerging mandarinfish ranavirus (MRV) both in natural and ISKNV-FKC vaccinated mandarinfish Siniperca chuatsi in Guangdong, South China, 2017. Aquaculture, 520 (2020) 734989.

24. Zhu Z, Dong C*., Weng S., He J*. (2019).Identification of outer membrane protein TolC as the major adhesin and potential vaccine candidate for Vibrio harveyi in hybrid grouper, Epinephelus fuscoguttatus (♀) × E. lanceolatus (♂). Fish Shellfish Immunol. 86:143-151.

23. Gao Y, Suárez Nicolás M., Wilkie Gavin S., Dong C, (2018). Bergmann Sven, Lee Pei Yu Alison, Davison Andrew J., Vanderplasschen Alain F. C.* and Boutier Maxime.2018. Genomic and biologic comparisons of cyprinid herpesvirus 3 strains. Vet Res(2018) 49:40.

22. Zhu Z, Dong C*, Weng S and He J*. (2018). The high prevalence of pathogenic Vibrio harveyi with multiple antibiotic resistance in scale drop and muscle necrosis disease of the hybrid grouper, Epinephelus fuscoguttatus (♀) × E. lanceolatus (♂), in China. J Fish Dis. 41(4):589-601.

21. Dong C*, Wang Z, Weng S and He J. (2017). Occurrence of a lethal ranavirus in hybrid mandarin (Siniperca scherzeri × Siniperca chuatsi) in Guangdong, South China. Vet microbiol,203,28-33.

20. Lee X, Weng S, Zhang H, Zeng J, He J* and Dong C* (2016). Identification and expression analysis of cellular and viral microRNAs in CyHV3-infected KCF-1 cells. Gene, 592(1):154-63.

19. Qi H, Yi Y, Weng S, Zou W, He J* and Dong C*., (2016). Differential autophagic effects triggered by five different vertebrate iridoviruses in a common, highly permissive mandarinfish fry (MFF-1) cell model. Fish Shellfish Immunol.49, 407-419.

18. Lee X, Yi Y, Weng S, Zeng J, Zhang H, He J* andDong C*., (2016). Transcriptomic analysis of koi (Cyprinus carpio) spleen tissue upon cyprinid herpesvirus 3 (CyHV3) infection using next generation sequencing. Fish Shellfish Immunol. 49, 213-224.

17. Yi, Y., Qi, H., Yuan, J., Wang, R., Weng, S., He, J., Dong, C*., (2015). Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome.Fish Shellfish Immunol. 45 (2), 757-770. 

16. Li, W., Lee, X., Weng, S., He, J*., Dong, C*. (2015). Whole-genome sequence of a novel Chinese cyprinid herpesvirus 3 isolate reveals the existence of a distinct European genotype in East Asia. Vet microbiol, 175, 185-194.

15. Dong C*, Shuang F, Weng S and He J. 2014. Cloning of a new fibroblast cell line from an early primary culture from mandarin fish (Siniperca chuatsi) fry for efficient proliferation of megalocytiviruses. Cytotechnology, 66:883–890.

14. Yi Y, Zhang H, Lee X, Weng S, He J and Dong C*. (2014). Extracellular virion proteins of two Chinese CyHV-3/KHV isolates, and identification of two novel envelope proteins. Virus Res 191, 108-116.

13. Xiang Z, Weng S, Qi H, He J and Dong C*. (2014). Identification and characterization of a novel FstK-like protein from spotted knifejaw iridovirus (genus Megalocytivirus). Gene, 545, 233-240.

12. Li, W., Zhang, X., Weng, S., Zhao, G., He, J., Dong, C.*. (2014). Virion-associated viral proteins of a Chinese giant salamander (Andrias davidianus) iridovirus (genus Ranavirus) and functional study of the major capsid protein (MCP). Vet Microbiol, 172, 129-139.

11. Dong C*, Li X, Weng S, Xie S and He J*. (2013). Emergence of fatal European genotype CyHV-3/KHV in mainland China. Vet microbiol, 162(1):239-44.

10. Shuang F, Luo Y, Xiong X, Weng S, Li Y, He J*, and Dong C**. (2013). Virion proteins of an RSIV type megalocytivirus from spotted knifejaw Oplegnathus punctatus (SKIV-ZJ07). Virology, 437(2): 89-99.

9. Dong C, Xiong X, Luo Y, Weng S, Wang Q and He J*. (2013). Efficacy of a formalin-killed cell vaccine against infectious spleen and kidney necrosis virus (ISKNV) and immunoproteomic analysis of its major immunogenic proteins. Vet microbiol,162(2-4): 419-428.

8. Dong, Y., Weng, S., He, J., Dong, C*. (2013). Field trial tests of FKC vaccines against RSIV genotype Megalocytivirus in cage-cultured mandarin fish (Siniperca chuatsi) in an inland reservoir. Fish Shellfish Immuno, l35, 1598-1603.

7. Dong C, Weng S, Li W, Li X, Yi Y, Liang Q, He J*. (2011). Characterization of a new cell line from caudal fin of koi, Cyprinus carpio koi, and first isolation of cyprinid herpesvirus 3 in China. Virus Res, 161(2):140-9. 

6. Dong C, Xiong X, Shuang F, Weng S, Zhang J, Zhang Y, Luo Y, He J*. (2011). Global landscape of structural proteins of infectious spleen and kidney necrosis virus. J Virol,;85(6):2869-77. 

5. Xiang Z, Dong C (Co-first authors), Qi L, Chen W, Huang L, Li Z, Xia Q, Liu D, Huang M, Weng S, He J*. (2010). Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio). Dev Comp Immunol, 34(12):1263-73.

4. Xiong X,Dong C, Weng S, Zhang J, Zhang Y, He J*. (2011). Antigenic identification of virion structural proteins from infectious spleen and kidney necrosis virus. Fish Shellfish Immunol, 31(6):919-24.

3. Xiong X, Dong C, Xu X, Weng S, Liu Z, He J*. (2011). Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Dev Comp Immunol, 35(4):431-40.

2. Dong C, Weng S, Luo Y, Huang M, Ai H, Yin Z, He J*. (2010). A new marine megalocytivirus from spotted knifejaw, Oplegnathus punctatus, and its pathogenicity to freshwater mandarinfish, Siniperca chuatsi. Virus Res, 147(1):98-106. 

1. Dong C, Weng S, Shi X, Xu X, Shi N, He J*. (2008). Development of a mandarin fish Siniperca chuatsi fry cell line suitable for the study of infectious spleen and kidney necrosis virus (ISKNV). Virus Res, 135(2):273-81.

（二）、发明专利或生物制品

1，发明专利：何建国，董传甫，殷志新，翁少萍。传染性脾肾坏病毒疫苗及其制备方法和应用，专利号：ZL200910038692.8。授权时间，2012.2。

2，新兽药证书：《鳜传染性脾肾坏死病灭活疫苗（NH0618株）》，农业农村部（一类）新兽药证书【（中华人民共和国农业农村部公告 第253号，（2019）新兽药证字75号）】，2019年12月30日。

（三）、国际学术会议：

1，Dong C *, Shuang F, Weng S, He J. Virion proteins of an RSIV type megalocytivirus from spotted knifejaw Oplegnathus punctatus (SKIV-ZJ07). XIX Poxvirus, Asfarvirus and Iridovirus conference. Salamanca in Spain, 25-29 June 2012. Presentation as a POSTER.

2，Dong C * and He J, A mini-review on fish iridovirus and iridoviral diseases: emphasis on Megalocytivirus. Asian Aquaculture Conference, 3-6 December, 2018, AIT BANKOK, THAILAND.