职称: 副教授
电子邮件: liufeng23@mail.sysu.edu.cn
导师类型: 博士生导师
学历: 博士
学科方向
071010-生物化学与分子生物学
0860-生物与医药
研究方向
1. 蛋白质互作与细胞衰老的机制
2. 应激条件下细胞时空蛋白组学动态分析
3. 基于邻近蛋白质组学的虚拟细胞构建
个人经历
2019至今 中山大学生命科学学院 副教授
2015-2019 中山大学生命科学学院 “百人计划” 讲师
2011-2014 美国加州大学旧金山分校（UCSF） 博士后
2005-2011 北京大学生命科学学院 理学博士
2001-2005 中山大学生命科学学院 理学学士
学术成就
中山大学生命科学学院“百人计划”引进人才，副教授，博士生导师，广东省杰出青年基金获得者。现任中山大学抗衰老研究中心副主任、中山大学生命科学学院生物化学系副主任、中国老年学和老年医学学会抗衰老分会委员、广东省生物化学与分子生物学学会理事、hLife杂志青年编委。以第一作者或通讯作者（含并列）在Nature Cell Biology （2篇）、Cell Research、Cell Reports（2篇）、Molecular Psychiatry等杂志发表研究论文，申请中国发明专利7项授权4项。担任Nature Communications等杂志审稿人。曾获北京大学优秀博士论文奖、强生亚洲优秀论文奖、中国生物化学与分子生物学会青年科学家论坛一等奖。
讲授课程
本科生必修课《生物化学 I》（广东省一流本科课程；中山大学一流本科课程）
本科生必修课《生物化学 II》
本科生必修课《大学生物》
本科生选修课《生物化学和分子生物学讨论课》
研究生必修课《高级生物化学》
论文专著
Jianxi Zhu#, Tuanwei Sun#, Fuxin Wei#, Dong Wang#, Feng Liu, Dongming Chen, Xian Liu, Chuanle Wang, Shengcheng Deng, Yue Yang, Yuanyan Xiong, Hongfei Xiang, Jiyu Li, Songbo Li*, Wenbin Ma*, Songyang Zhou*. Targeting ROAM1 with UDP-GlcNAc nanosheets selective activates lysosomal AMPK to resolve metabolic dysfunction-associated steatotic liver disease. Bioactive Materials. 2026 Jul 12:66:487-507. doi: 10.1016/j.bioactmat.2026.06.047.
Zhifen Zhou, Kunling Huang, Ruofei Li, Yuxi Chen, Song Lin, Shengcheng Deng, Zibin He , Juan Chen, Jun Lu, Yunying Liu, Wenbin Ma, Su Wu*, Feng Liu*, Zhou Songyang*. SUDS3 nuclear condensates decelerate DNA replication and safeguard genome stability. Cell Reports. 2026 Jul 28;45(7):117713. doi: 10.1016/j.celrep.2026.117713.
Ruofei Li#, Yingying Li#, Su Wu#, Zhifen Zhou, Xinyu Hou, Ping Yang, Jun Zhu, Ying Xia, Wenchao Wu, Ran Feng, Qiuyuan Gao, Kunling Huang, Yi Liu, Jianfei Zheng , Xiaoqin Zhong, Hui Huang, Cheng Chang, Wenbin Ma, Zhou Songyang*, Feng Liu*. Proximal proteomics reveals a landscape of human nuclear condensates. Nature Cell Biology. 2025 Dec;27(12):2198-2213. doi: 10.1038/s41556-025-01809-4.
Ran Feng#, Feng Liu#*, Ruofei Li, ZhifenZhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, YingXia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu* and Zhou Songyang*. The Rapid Proximity Labeling System PhastID identifies ATP6AP1 as an unconventional GEF for Rheb. Cell Research. (Cover Article) 2024 May;34(5):355-369. doi: 10.1038/s41422-024-00938-z.
Bohong Chen#, Tianyu Ge#, Meiqi Jian, Liutao Chen, Zhengwen Fang, Zibin He, Chengjing Huang, Yan An, Shanshan Yin, Yuanyan Xiong, JingKai Zhang, Ruofei Li, Miaoman Ye, Yubing Li, Feng Liu, Wenbin Ma, Zhou Songyang. Transmembrane nuclease NUMEN/ENDOD1 regulates DNA repair pathway choice at the nuclear periphery. Nature Cell Biology. 2023 Jun 15. doi: 10.1038/s41556-023-01165-1.
Aging Biomarker Consortium;..., Feng Liu#, et al. Biomarkers of aging. Science China Life Sciences. (Cover Article) 2023 Apr 11. doi: 10.1007/s11427-023-2305-0.
Jingwen Wang#, Jiahui Liu#, Miaoman Ye, Feng Liu, Su Wu, Junjiu Huang and Guang Shi*. Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex. Stem Cell Research & Therapy. 2020:11(314).
Su Wu#*, Siyao Xu#,Ruofei Li, Kecheng Li, Xiaoqin Zhong, Yingying Li, Zhifen Zhou, Yi Liu, Ran Feng, Jianfei Zheng, Zhou Songyang*, Feng Liu*. mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts. Frontiers in Cell and Developmental Biology. 11 December 2019. https://doi.org/10.3389/fcell.2019.00337.
Jianxi Zhu, Mingyang Xu, Yi Liu, Lisha Zhuang, Kejun Ying, Feng Liu, Dan Liu, Wenbin Ma*, Zhou Songyang*. Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation. Protein & Cell. 2018, Nov 14. doi: 10.1007/s13238-018-0593-9.
Yumei Liao#, Xiaoji Zhuang#, Xiaojie Huang, Yinghui Peng, Xuanyue Ma, Zhi-Xing Huang, Feng Liu, Junyu Xu, Ying Wang, Wei-Min Chen*, Wen-Cai Ye*, Lei Shi*. A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors. Frontiers in Pharmacology. 2018; Apr 5;9:290.
Yi Liu#, Feng Liu#*, Yizhao Cao, Huimin Xu, Yangxiu Wu, Su Wu, Dan Liu, Yong Zhao, Zhou Songyang*, Wenbin Ma*. Shwachman-Diamond Syndrome Protein SBDS Maintains Human Telomeres by Regulating Telomerase Recruitment. Cell Reports. 2018;22:1849-1860. (IF: 8.2)
Huan Yang#, Su Wu#, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu*, Yuqing Chen*. Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats. Stem Cell Research & Therapy. 2017:8(267).
Sophie Laguesse, Nadege Morisot, Jung Hoon Shin, Feng Liu, Martin F. Adrover, Samuel A. Sakhai, Marcelo F. Lopez, Khanhky Phamluong, William C. Griffin III, Howard C. Becker, Kevin J. Bender, Veronica A. Alvarez, Dorit Ron*. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron. 2017;96(1):145-159.
Feng Liu, Xuyang Feng, Wenbin Ma*. Analysis of Telomere Proteins by Chromatin Immunoprecipitation (ChIP). Methods in Molecular Biology. 2017;1587:205-214.
Feng Liu, Sophie Laguesse, Remi Legastelois, Nadege Morisot, Sami Ben Hamida, Dorit Ron*. mTORC1-dependent Translation of Collapsin Response Mediator Protein-2 Drives Neuroadaptations Underlying Excessive Alcohol Drinking Behaviors. Molecular Psychiatry. 2017;22:89-101.
Emmanuel Darcq, Vincent Warnault, Khanhky Phamluong, Gabriel M Besserer, Feng Liu, Dorit Ron*. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Molecular Psychiatry. 2015;20(10):1219-31.
Segev Barak, Feng Liu, Sami Ben Hamida, Quinn V Yowell, Jeremie Neasta, Viktor Kharazia, Patricia H Janak, Dorit Ron*. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nature Neuroscience. 2013;16(8):1111-7.
Feng Wang, Weiwei Xia, Feng Liu, Ji Li, Gang Wang, Jun Gu*. Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axismediates 25- hydroxycholesterol- induced interleukin-8 production in atherosclerosis. Cardiovascular Research.2012;93(1):190-9.
Feng Liu#, Su Wu#, Hongwei Ren, Jun Gu*. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nature Cell Biology. 2011;13(3):254-62.
Feng Liu, Jun Gu*. Retinoic acid inducible gene-I, more than a virus sensor. Protein & Cell. 2011;2(5):351-7.
Lijuan Xu#, Nengming Xiao#, Feng Liu, Hongwei Ren, Jun Gu*. Inhibition of RIG-I and MDA5-dependentantiviral response by gC1qR at mitochondria. Proceedings of the National Academyof Sciences of the United States of America. 2009;106(5):1530-5.
#并列第一作者 *通讯或共同通讯作者
