个人主页: http://orcidorg/0000-0002/4709-1507
团队主页: https://lab.rjmart.cn/10028/B0800D6A322BE725
电子邮件: laidehua@mail.sysu.edu.cn
导师类型: 博士生导师
学科方向:
071002-动物学
071005-微生物学
071009-细胞生物学
071010-生物化学与分子生物学
0860-生物与医药

研究方向

分子寄生虫学及进化

寄生虫是一类特殊的动物，需要寄生在一个或多个宿主体内。我们不仅研究寄生虫的形态、生活史、感染力、抗药性等基本寄生虫学特征，还研究基因及蛋白功能与进化。

招生专业：微生物学（硕士）/动物学（博士）/生物医药与健康（博士）

个人经历

讲授课程

滨海动物学实习（本科大一暑假）

生物化学（本科大二第一学期）

学术规范与论文写作（研究生第一年第二学期）

学术成就

一直从事人兽共患寄生虫的研究，并取得显著成绩，2005年迄今，在PNAS、the Lancet Infectious Diseases和Molecular Biology and Evolution等国际顶级学术期刊杂志发表论文多篇，SCI论文八十余篇，影响因子10及以上有十余篇，得到寄生生物领域国内外同行认可。

研究成果加深了学术界对寄生生物的生物学特性在细胞，蛋白及分子水平上的认识，在物种形成及进化等宏观方面做出了积极贡献，也为寄生虫的控制及药物靶点设计提供了重要的理论基础。
 

获广东省杰青项目、欧盟居里夫人基金访问学者项目、瑞典国际科学基金青年项目、广州市珠江新星等人才计划资助。

承担课题

主持的科研基金:

2023  –  2026       国家自然科学基金面上项目(32270446) 
布氏锥虫基体蛋白BBLP调节基体组装的分子机制

2022  –  2024       广州市基础研究计划基础与应用基础研究项目（涉农项目）(202201011831) 
草鱼华支睾吸虫（肝吸虫）感染防控关键技术研究

2022  –  2024       广东省自然科学基金面上项目(2022A1515011874) 
利用锥虫模型研究中心体关键蛋白的功能

2018  –  2021      国家自然科学基金面上项目(31772445)
利用iNOS基因敲除大鼠研究宿主NO对弓形虫增殖与分化的调控

2016  –  2020      广东省自然科学基金杰出青年项目(2016A030306048)
人畜共患病原体锥虫的遗传特性及分化调控

2015  –  2018      广州市珠江科技新星专项项目(201506010011)
人畜共患锥虫的遗传特性及分化调控

2015  –  2017      国家自然科学基金青年项目(31402029)
利用布氏锥虫BBCP 蛋白研究真核生物中心体的蛋白组成及蛋白功能

参加的科研基金:

2018 –  2022      国家自然科学基金重点国际合作项目(31720103918) PAG基因家族功能及其在锥虫分化中的作用

2017  –  2021      国家重点研发计划畜禽重大疫病防控与高效安全养殖综合技术研发(2017YFD0500400)畜禽重要胞内寄生原虫的寄生与免疫机制研究1856万

2016  –  2018      国家重点研发计划生物安全关键技术专项(2016YFC1200500)重要热带病传播相关的入侵媒介生物及其病原体的生物学特性研究1277万

2015  –  2018      广东省自然科学基金重点项目(2015A030311042)布氏锥虫分化机理的分子基础

代表性论文专著

1. Luo JY, Wang JF, Yang J, Zhang P, Hide G, Lai DH*, Lun ZR. (2025) Thermo-related degeneration of stumpy forms of Trypanosoma brucei, the pathogen of African sleeping sickness. Adv Biotechnol (Singap). 3(4):28. doi: 10.1007/s44307-025-00081-9. 
2. Li Q, Luo JY, Fu C, Kang W, Wang L, Tong H, Lun Z, Zhang Q, Lai DH*, Liu H*. (2025) Discovery of novel CRK12 inhibitors for the treatment of human African trypanosomiasis: an integrated computational and experimental approach. Pharmaceuticals  18(6):778. 
3. Wang JF, Li XT, Zhang P, Xu LW, Zhang JY,Hide G, Lai DH*, Lun ZR. (2025) Characterization of a trypanosome from large yellow croaker (Larimichthys crocea), cage-cultured in seawater, in China. Aquacult Rep 43:102868.
4. Zhou JY, Xu L, Bi YX, Zhang J, Geoff Hide, Lai DH*, Lun ZR. (2024) First outbreak of trypanosomiasis in farmed blood parrot cichlids (Vieja melanura♀ × Amphilophus citrinellus♂) from southern China. Aquaculture. 588:740944. 
   doi:10.1016/j.aquaculture.2024.740944. 
5. Zhixun Li, Wenjing Du, Jiong Yang, De-Hua Lai, Zhao-Rong Lun, Qiang Guo. (2023) Cryo-electron tomography of Toxoplasma gondiiindicates that the conoid fiber may be derived from microtubules. Advanced Sciences. 2206595.
6. Yang J, Long S, Hide G, Lun ZR, Lai DH*. (2024) Apicomplexa micropore: history, function, and formation. Trends in Parasitology. 40(5): 416–426. doi:10.1016/j.pt.2024.03.008
7. Wan W#, Dong H#, Lai DH#, Yang J, He K, Tang X, Liu Q, Hide G, Zhu XQ, Sibley LD, Lun ZR, Long S*. (2023) The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nat Commun 14:977. doi:10.1038/s41467-023-36571-4
8. Chen K, Zhang P, Yang TB, Wen YZ, Hide G, Lun ZR*, Lai DH*. (2022) Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and fresh water fish trypanosomes. Exp Parasitol. 239:108288.
9. Su BX, Wang JF, Yang TB, Hide G, Lai DH*, Lun ZR*. (2022) A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. Int J Parasitol 52:253–264. doi: 10.1016/j.ijpara.2021.10.009
10. Chen YF#, Liao L-F#, Wu N, Gao JM, Zhang P, Wen YZ, Hide G, Lai DH*, Lun ZR*. (2021) Species identification and phylogenetic analysis ofLeishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People’s Republic of China. PLoS Negl. Trop. Dis. 15(12): e0010055. (Onlined) Doi: 10.1371/journal.pntd.0010055
11. Wang ZJ, Yu SM, Gao JM, Zhang P, Hide G, Yamamoto M, Lai DH*, Lun ZR*. (2021) High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats. iScience. 24:103280. doi: 10.1016/j.isci.2021.103280
12. Lai DH*, Moreira-Leite F, Xu ZS, Yang J, Gull K. (2021) A specific basal body linker protein provides the connection function for basal body inheritance in trypanosomes. Proc. Natl. Acad. Sci. USA. 118(8): e2014040118.
13. Li SJ, Zhang X, Lukeš J, Li BQ, Wang JF, Qu LH, Hide G, Lai DH*, Lun ZR. (2020) Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi. Nucl. Acids Res. 48(17):9747–9761. 25 Sep, doi: 10.1093/nar/gkaa700
14. Xiong J#, Chen JP#, Chen XG#,..., Lai DH#, et al. (2019) Progress of protozoological studies in China: Hot spots and new patterns (in Chinese).  Sci Sin Vitae. 49(10):1301–1322. doi:10.1360/SSV-2019-0127[熊杰#, 陈建平#, 陈晓光#,...赖德华#, 等. 进展中的原生动物学研究: 热点领域与新格局 (2019) 中国科学: 生命科学. 49(10):1301–1322]
15. An R, Tang Y, Chen L, Cai H, Lai DH, Liu K, Wan L, Gong L, Yu L, Luo Q, Shen J, Lun ZR,  Ayala FJ, Du J. (2018) Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients. Pro. Nat. Acad. Sci. USA. 115(23):E5344–E5352. doi: 10.1073/pnas.1801118115
16. Shen J#, Lai DH#, Wilson RA, Chen YF, Wang LF, Yu ZL, Li MY, He P, Hide G, Sun X, Yang TB, Wu ZD*, Ayala FJ*, Lun ZR*. (2017) Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proc. Natl. Acad. Sci. USA. 114 (38): 10214–10219. doi: 10.1073/pnas.1708578114. (影响因子: 9.6) 2017.9.5
17. Qin A#, Lai DH#, Liu Q#, Huang W#, Wu Y, Chen X, Yan S, Xia H, Hide G, Lun ZR*, Ayala FJ*, Xiang* AP. (2017) Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc. Natl. Acad. Sci. USA.  114(6):1365–1370. (影响因子: 9.6) 2017.2.7
18. 赖德华，吴娜，谢祎婷，洪晓昆，陈允甫，廖力夫，伦照荣*. (2016)一例输入性皮肤利什曼病病原体的鉴定. 中国寄生虫学与寄生虫病杂志34(3):295–296,封3. [Lai DH, Wu N, Xie YT, Hong XK, Chen YF, Liao LF, Lun ZR*. (2016) Pathogen Identification in an Imported Case of Cutaneous Leishmaniasis. Chin. J. Parasitol. Parasit. Dis. 34(3):295-296.]  国家核心期刊
19. Lun ZR*, Lai DH, Wen YZ, Zheng LL, Shen JL, Yang TB, Zhou WL, Qu LH, Hide G*, Ayala FJ* (2015) Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proc. Natl. Acad. Sci. USA. July 112(29):8835–8842. (影响因子: 9.6)
20. Carnes J, Anupama A, Balmer O, Jackson A, Lewis M, Brown R, Cestari1 I, Desquesnes M, Gendrin C, Hertz-Fowler C, Imamura H, Ivens A, Koreny L, Lai DH, MacLeod A, McDermott SM, Merritt C, Monnerat S, Moon W, Myler P, Phan I, Ramasamy G, Sivam D, Lun ZR*, Lukeš J*, Stuart K*, Schnaufer A* (2015) Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. PLOS Negl. Trop. Dis. 9(1):e3404. (影响因子:4.4)
21. Gao JM, Yi SQ, Wu MS, Geng GQ, Shen JL, Lu FL, Hide G, Lai DH*, Lun ZR* (2015) Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Exp. Parasitol. 149(1): 47–53. (影响因子: 1.6)
22. Xie YT, Lai DH, Liu GY, Zhou JL, Lun ZR* (2015) Severe fever with thrombocytopenia syndrome in China. Lancet Infect. Dis.  February 15(2): 145. (影响因子: 4)
23. Desquesnes M, Holzmuller P, Lai DH, Dargantes A, Lun ZR, Jittapalapong S (2013)  Trypanosoma evansi and surra: A review and perspectives on origin, history & distribution, taxonomy, morphology, hosts and pathogenic effects. BioMed. Res. Int. 194176 Aug 19 (影响因子: 2.9)
24. Desquesnes M, Holzmuller P, Lai DH, Dargantes A, Lun ZR, Jittapalapong S (2013)  Trypanosoma evansi and surra: A review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects. BioMed Res Int.321237 Sep 18 (影响因子: 2.9)
25. Janouskovec J, Sobotka R(equal contribution),  Lai DH (共同第一作者), Flegontov P, Koník P, Komenda J, Ali S, Prásil O, Pain A, Oborník M, Lukes J, Keeling PJ (2013) Split photosystem protein, linear-mapping topology and growth of structural complexity in the plastid genome of Chromera velia. Mol Biol Evol. Nov;30(11):2447–62. doi: 10.1093/molbev/mst144. (影响因子: 10.4)
26. Lai DH*, Bontempi EJ*, Lukeš J (2012) Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion. Mol. Biochem. Parasitol. 183(2):189–192. (影响因子: 2.9)
27. Wang MH, Wen YZ, Wei Y, Lai DH, Bengaly Z, Desquesnes M, Lun ZR (2012) Mitogen-activated protein kinase 5, a novel molecular marker for the identification and detection of Trypanozoon species Acta Trop. 122(2):183–188. (影响因子: 2.3)
28. 余新炳沈继龙 主编 赖德华 等编者 (2011) 现代病原生物学研究技术 人民卫生出版社 专著
29. Lun ZR#*, Lai DH#, Li FJ,  Lukeš J, Ayala FJ. (2010) Trypanosoma brucei: two steps to spread out from Africa.Trends Parasitol. 2010 Sep 26(9): 424–427. (影响因子: 4.9)
30. Lai DH, Wang QP, Li Z, Lukins AG, Reid SA, Lun ZR. (2010) Investigations into human serum sensitivity expressed by stocks of Trypanosoma brucei evansi. Int. J. Parasitol. 40(6): 705–710. (影响因子: 3.8)
31. Lai DH*, Wang QP, Li Z, Lukeš J, Lun ZR. (2009) Evolution of the serum resistance-associated SRA gene in African trypanosomes. Chin. Sci. Bull. 54(7):1275–1278. (影响因子: 1.0)
32. Lai DH, Hashimi H, Lun ZR, Ayala FJ, Lukeš J. (2008) Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. Proc. Natl. Acad. Sci. USA105(6): 1999–2004. (影响因子: 9.6)
33. Lai DH, Wang QP, Chen W, Cai LS, Wu ZD, Zhu XQ, Lun ZR. (2008) Molecular genetic profiles among individual Clonorchis sinensis adults collected from cats in two geographic regions of China revealed by RAPD and MGE-PCR methods. Acta Trop. 107(2): 213–216. (影响因子: 2.2)
34. Wang QP, Lai DH, Zhu XQ, Chen XG, Lun ZR. (2008) Human angiostrongyliasis. Lancet Infect. Dis. Aug 8(10): 621–630. (影响因子: 16.1)
35. 戴晓俐, 赖德华, 伦照荣. (2006) 四种抗寄生原虫药物对伊氏锥虫、马媾疫锥虫和布氏锥虫感染的治疗作用. 热带医学杂志 6卷12期1240-1244,1248国家核心期刊
36. Lun ZR, Gasser RB, Lai DH, Li AX, Zhu XQ, Yu XB and Fang YY. (2005) Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect. Dis. 5(1): 31–41. (影响因子: 10.8)