闫浩
性别: 男
职称: 副教授
学历: 博士
办公室：生命科学2号楼1024室
Email: yanh66@mail.sysu.edu.cn
研究方向
本课题组聚焦于核酸化学生物学前沿方法开发，旨在深化对生命过程的理解，并推动健康领域的进步。随着核酸测序、CRISPR系统等技术的快速发展，人们对核酸的认知与操控能力实现了质的飞跃。目前，我们已经能够对基因组特定区域进行编辑，在RNA层面调控蛋白质编码信息，并运用寡核苷酸或小分子等手段干预RNA的结构与功能。这些技术为生物医学研究与疾病治疗开辟了广阔的应用前景。以核酸为靶点的疾病治疗策略，突破了传统药物主要靶向蛋白质的局限，尤其为那些缺乏可成药蛋白靶点的疾病提供了新的治疗可能。然而，这些技术迈向临床仍面临诸多挑战：现有基因编辑工具普遍存在脱靶风险、递送效率低、器官选择性不足等安全性问题；而RNA靶向调节剂（尤其是小分子）则种类有限、结合力弱、选择性欠佳。
针对上述挑战，课题组围绕核酸的编辑、修饰、剪接及调控等关键化学过程开展研究，致力于发展面向核酸靶点治疗的创新方法。主要研究方向包括：
1）新型精准基因编辑工具的开发
2）组织特异性基因递送体系的构建
3）靶向RNA的小分子药物筛选平台建设
加入我们
我们秉持开放、包容、协作的科研文化，鼓励学生跨越学科界限，勇于探索创新。欢迎对生命科学和化学交叉领域有浓厚兴趣的同学加入我们的团队！
目前课题组拟招收博士后、博士研究生、硕士研究生及科研助理（本科及以上学历）若干名。学科背景包括但不限于生物和化学等相关领域。岗位待遇参照中山大学和广州市相关政策执行。我们常年欢迎校内外本科生（不限学科背景）参观访问，参与科研训练，探索科学前沿。如有意向，请将个人简历以及其他科研成果证明材料以单个PDF文件发送至：yanh66@mail.sysu.edu.cn，邮件主题注明：应聘职位+姓名。
个人经历
2025.08-至今 中山大学生命科学学院 副教授
2020.03-2025.07 芝加哥大学化学系 博士后
2018.07-2020.02 凯斯西储大学化学系 博士后
2014.01-2018.06 新墨西哥大学化学与化学生物学系 博士
2011.07-2013.07 康龙化成（西安）新药技术有限公司 化学研究员
2008.09-2011.07 北京师范大学化学学院 硕士
2004.08-2008.07 北京师范大学化学学院 本科
论文发表1-21
1. Xu, C.; Niu, X.; Sun, H.; Yan, H.; Tang, W.; Ke, A., Conversion of IscB and Cas9 into RNA-guided RNA editors. Cell 2025,188 (21), 5847-5861.e11.
2. Shmidov, E.; Villani, A.; Mendoza, S. D.; Avihu, E.; Lebenthal-Loinger, I.; Karako-Lampert, S.; Shoshani, S.; Ye, C.; Wang, Y.; Yan, H.; Tang, W.; Bondy-Denomy, J.; Banin, E., Multigenerational proteolytic inactivation of restriction upon subtle genomic hypomethylation in Pseudomonas aeruginosa. Nature microbiology 2025,10 (10), 2498-2510.
3. Nguyen, H. T. X.; Kim, B.-G.; Myers, J. T.; Yan, H.; Kumar, S.; Eid, S.; Wang, W.; Huang, A. Y.; Liang, F.-S., Engineering TME-gated inducible CAR-T cell therapy for solid tumors. Molecular Therapy 2025,33 (8), 3546-3558.
4. Yan, H.; Tang, W., Programmed RNA editing with an evolved bacterial adenosine deaminase. Nature Chemical Biology 2024,20 (10), 1361-1370.
5. Yan, H.; Tan, X.; Zou, S.; Sun, Y.; Ke, A.; Tang, W., Assessing and engineering the IscB–ωRNA system for programmed genome editing. Nature Chemical Biology 2024,20 (12), 1617-1628.
6. Xiao, Y.; Chen, Y.-M.; Zou, Z.; Ye, C.; Dou, X.; Wu, J.; Liu, C.; Liu, S.; Yan, H.; Wang, P.; Zeng, T.-B.; Liu, Q.; Fei, J.; Tang, W.; He, C., Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing. Nature Methods 2024,21 (2), 247-258.
7. Wu, T.; Liu, C.; Zou, S.; Lyu, R.; Yang, B.; Yan, H.; Zhao, M.; Tang, W., An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity. Nature Chemical Biology 2023,19 (11), 1384-1393.
8. Bhattarai, U.; Hsieh, W.-C.; Yan, H.; Guo, Z.-F.; Shaikh, A. Y.; Soltani, A.; Song, Y.; Ly, D. H.; Liang, F.-S., Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor. Bioorganic & Medicinal Chemistry 2020,28 (7), 115394.
9. Yan, H.#; Zhou, M.#; Bhattarai, U.; Song, Y.; Zheng, M.; Cai, J.; Liang, F.-S., Cyclic Peptidomimetics as Inhibitor for miR-155 Biogenesis. Molecular Pharmaceutics 2019,16 (2), 914-920.
10. Yan, H.; Liang, F.-S., miRNA inhibition by proximity-enabled Dicer inactivation. Methods 2019,167, 117-123.
11. Zhao, W.; Nguyen, H.; Zeng, G.; Gao, D.; Yan, H.; Liang, F.-S., A chemically induced proximity system engineered from the plant auxin signaling pathway. Chemical Science 2018,9 (26), 5822-5827.
12. Yan, H.; Bhattarai, U.; Song, Y.; Liang, F.-S., Design, synthesis and activity of light deactivatable microRNA inhibitor. Bioorganic Chemistry 2018,80, 492-497.
13. Yan, H.; Bhattarai, U.; Guo, Z.-F.; Liang, F.-S., Regulating miRNA-21 Biogenesis By Bifunctional Small Molecules. Journal of the American Chemical Society 2017,139 (14), 4987-4990.
14. Chen, T.; Gao, D.; Zhang, R.; Zeng, G.; Yan, H.; Lim, E.; Liang, F.-S., Chemically Controlled Epigenome Editing through an Inducible dCas9 System. Journal of the American Chemical Society 2017,139 (33), 11337-11340.
15. Yan, H.; Yue, P.; Li, Z.; Guo, Z.; Lu, Z., Syntheses of bifunctional molecules containing 12 aneN(3) and carbazol moieties as effective DNA condensation agents. Science China-Chemistry 2014,57 (2), 296-306.
16. Yan, H.; Li, Z.-F.; Guo, Z.-F.; Lu, Z.-L.; Wang, F.; Wu, L.-Z., Effective and reversible DNA condensation induced by bifunctional molecules containing macrocyclic polyamines and naphthyl moieties. Bioorganic & Medicinal Chemistry 2012,20 (2), 801-808.
17. Song, Y.; Zan, J.; Yan, H.; Lu, Z.-L.; Wang, R., Steric effects on the catalytic activities of zinc(II) complexes containing 12 aneN(3) ligating units in the cleavage of the RNA and DNA model phosphates. Organic & Biomolecular Chemistry 2012,10 (38), 7714-7720.
18. Li, Z.-F.; Guo, Z.-F.; Yan, H.; Lu, Z.-L.; Wu, D.-Y., Syntheses of 12 aneN(3)-oligopeptide conjugates as effective DNA condensation agents. Bioorganic & Medicinal Chemistry 2012,20 (9), 2897-2904.
19. Guo, Z.-F.; Yan, H.; Li, Z.-F.; Lu, Z.-L., Synthesis of New 12 aneN(3) Compounds and Their Catalytic Cleavage of Phosphodiester. Chemical Journal of Chinese Universities-Chinese 2011,32 (9), 2128-2132.
20. Guo, Z.-F.; Yan, H.; Li, Z.-F.; Lu, Z.-L., Synthesis of mono-and di- 12 aneN(3) ligands and study on the catalytic cleavage of RNA model 2-hydroxypropyl-p-nitrophenyl phosphate with their metal complexes. Organic & Biomolecular Chemistry 2011,9 (19), 6788-6796.
21. Zan, J.; Yan, H.; Guo, Z.-f.; Lu, Z.-L., Efficient syntheses of artificial nucleases containing mono-, di- and tri- 12 aneN(3) ligating units through click chemistry. Inorganic Chemistry Communications 2010,13 (9), 1054-1056.
